I think the issue isn't that Samus is a gene spliced suprahuman, it's the worry that Ravenous would toy with Samus being a feral gene spliced suprahuman, therefore losing her humanity even more.
Seconding this opinion actually. I could see the "ravenous" portion going two ways:
1. Either the weird schism inside the Galactic Federation coming to a head since Dread dropped a hint with the EMMI (perhaps a continuation of what was established in Fusion with their hunger for a capable bioweapon?) or ..
2. Samus gets some sort of new horrific ability (perhaps a set? Does the suit evolve to "higher" metroid stages?) as a result of the newly unlocked Metroid suit that she can put to good use.
It would fucking suck if they just made her feral in general because she's not a killdroid nor is she helpless, but she's ruthless when it's
good and necessary to be so. Plus Dread had a few moments where the glowy-metroid-hand was acting up that seemed to imply (at least from what I saw) she recognized there was an powerfully addictive aspect to it, and still soldiered on since Raven Beak was a megalomaniac that had to be stopped at all costs.
Samus has to hide out on a planet while avoiding the assassin bots sent after her, all the while she's becoming more and more feral.
If the GalFed DOES become relevant again (specifically whatever group is fucking around and responsible for the suspiciously low bounty for retrieving the EMMI), I could see the conflict being less that Samus is feral (the new abilities could make it SEEM that way when it isn't actually the case, she's completely in control) and more so that the legacy of the Metroids casts a long shadow as one of the most terrifying predators that had to be rendered extinct for fear of their weaponization. That long of a struggle has staying power in people's minds.
Story-wise I can imagine a setup where the Metroids fearsome nature and the splinter GalFed group's word is set up against her. She
is a legendary bounty hunter, and she's still fighting and adapting to the new suit (and whatever comes with it without slipping into mindless temptation), but the "feral" aspect is coming more from the paranoia and fear building up around her powers which ends up tarnishing her image and making people doubt their trust in her. I don't imagine that'd stop her from trying to do the right thing regardless, and ADAM's still with her and might help tie up the corruption plot that started in Fusion (assuming not all of it was rooted out by Dread, hence the EMMI). So, any leftover splinters of the GalFed group that was implied to have been investigated at the end of Fusion could be seeing this as a chance to "take care" of the problem that blew their cover in the first place, and that'd be what kicks everything off.