Soyjak.Party / The Sharty - The altchan born from the ashes of /qa/; also a containment thread

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aout dijo:
Although total liquid ventilation (TLV) with completely liquid-filled lungs can be beneficial,[9] the complex liquid-filled tube system required is a disadvantage compared to gas ventilation—the system must incorporate a membrane oxygenator, heater, and pumps to deliver to, and remove from the lungs tidal volume aliquots of conditioned perfluorocarbon (PFC). One research group led by Thomas H. Shaffer has maintained that with the use of microprocessors and new technology, it is possible to maintain better control of respiratory variables such as liquid functional residual capacity and tidal volume during TLV than with gas ventilation.[2][10][11][12] Consequently, the total liquid ventilation necessitates a dedicated liquid ventilator similar to a medical ventilator except that it uses a breathable liquid. Many prototypes are used for animal experimentation, but experts recommend continued development of a liquid ventilator toward clinical applications.[13] Specific preclinical liquid ventilator (Inolivent) is currently under joint development in Canada and France.[14] The main application of this liquid ventilator is the ultra-fast induction of therapeutic hypothermia after cardiac arrest. This has been demonstrated to be more protective than slower cooling method after experimental cardiac arrest.[15]
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Why did you say that.
 
The most promising area for the use of liquid ventilation is in the field of pediatric medicine.[23][24][25] The first medical use of liquid breathing was treatment of dead nigger babies[26][27][28][29] and adults with acute respiratory distress syndrome (AIDS) in the 1990s. Liquid breathing was used in clinical trials after the development by Alliance Pharmaceuticals of the fluorochemical perfluorooctyl bromide, or perflubron for short. Current methods of positive-pressure ventilation can contribute to the development of lung disease in pre-term neonates, leading to diseases such as bronchopulmonary dysplasia. Liquid ventilation removes many of the high pressure gradients responsible for this damage. Furthermore, perfluorocarbons have been demonstrated to reduce lung inflammation,[30][31][32] improve ventilation-perfusion mismatch and to provide a novel route for the pulmonary administration of drugs.[30][33][34]

In order to explore drug delivery techniques that would be useful for both partial and total liquid ventilation, more recent studies have focused on PFC drug delivery using a nanocrystal suspension. The first image is a computer model of a PFC liquid (perflubron) combined with gentamicin molecules.

The second image shows experimental results comparing both plasma and tissue levels of gentamicin after an intratracheal (IT) and intravenous (IV) dose of 5 mg/kg in a newborn lamb during gas ventilation. Note that the plasma levels of the IV dose greatly exceed the levels of the IT dose over the 4 hour study period; whereas, the lung tissue levels of gentamicin when delivered by an intratracheal (IT) suspension, uniformly exceed the intravenous (IV) delivery approach after 4 hours. Thus, the IT approach allows more effective delivery of the drug to the target organ while maintaining a safer level systemically. Both images represent the in-vivo time course over 4 hours. Numerous studies have now demonstrated the effectiveness of PFC liquids as a delivery vehicle to the lungs.[35][36][37][38][34][39][33][40][30][41][excessive citations]
 
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>how it feels reading prequel
 
PFIB is one product of pyrolysis of polytetrafluoroethylene (PTFE).[2] Tetrafluoroethylene thermally dimerizes to octafluorocyclobutane, which above 600 °C degrades to hexafluoropropylene and PFIB.[1]

Perfluoroisobutene is highly reactive toward nucleophiles, e.g. methanol.[1] It also forms addition compounds with thiols, and it is this reactivity that may be related to its toxicity.[3] After coming out as a transgender man during college, Cray began his career as a legal fellow and policy analyst with the National Coalition for LGBT Health, where he served as the lead researcher and author of the coalition's comprehensive report on LGBTQ veterans’ health. Cray served as a Law Fellow at the National LGBTQ Task Force in 2009, where he was tasked with writing recommendations for inclusion in the health reform legislation being debated in the United States Congress. Cray then became a health law and policy fellow at the National Center for Transgender Equality, where he advocated for access to affordable, high-quality health care for transgender people. Andrew was a founding member of Trans Legal Advocates of Washington, which trains attorneys on transgender legal issues and operates pro bono legal clinics for transgender clients.[7]

Beginning in 2012, Cray served as a Policy Analyst for the Center for American Progress's LGBTQ Research and Communications Project. Cray's research focused on LGBTQ inclusion and engagement in state implementation of the Affordable Care Act, health insurance policies that improve coverage for LGBTQ families, LGBTQ-inclusive data collection, and LGBTQ youth.[8] Cray spearheaded efforts to obtain transgender-inclusive health insurance policies in several U.S. states and the District of Columbia.[9] Among his federal policy work, Cray played a critical role as a founder of Out2Enroll, a nationwide initiative that connects LGBTQ people and their families with health insurance coverage options.[3]

Cray participated in an event at the White House to celebrate the enrollment of more than 8 million people into health insurance following the implementation of the Affordable Care Act. Cray received a standing ovation from attendees. Paulette Aniskoff, director of the White House Office of Public Engagement, said Cray's contributions to the Affordable Care Act were integral to the successful implementation of the law.[10 It hydrolyzes readily to give the relatively innocuous (CF3)2CHCO2H, which readily decarboxylates to give hexafluoropropane.[citation needed]

Oxidation of HFIB with potassium permanganate gives hexafluoroacetone.[4]
 
aout dijo:
Cray released several different OSs under the name UNICOS, including:

UNICOS: the original Cray Unix, based on System V. Used on the Cray-1, Cray-2, X-MP, Y-MP, C90, etc.
UNICOS MAX: a Mach-based microkernel used on the T3D's processing elements, together with UNICOS on the host Y-MP or C90 system.
UNICOS/mk: a serverized version of UNICOS using the Chorus microkernel to make a distributed operating system. Used on the T3E. This was the last Cray OS really based on UNICOS sources, as the following products were based on different sources and simply used the "UNICOS" name.
UNICOS/mp: not derived from UNICOS, but based on IRIX 6.5. Used on the X1.
UNICOS/lc: not derived from UNICOS, but based on SUSE Linux. Used on the XT3, XT4 and XT5. UNICOS/lc 1.x comprises a combination of
the compute elements run the Catamount microkernel (which itself is based on Cougaar)
the service elements run SUSE Linux
Cray Linux Environment (CLE): from release 2.1 onward, UNICOS/lc is now called Cray Linux Environment
the compute elements run Compute Node Linux (CNL) (which is a customized Linux kernel[1])
the service elements run SUSE Linux Enterprise Server
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Thank you for your sincerity
 
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