- The tribe ingame is the Wapiti Tribe, essentially a mish-mash of different native tribes of the Plains and the Rocky Mountains
- Three treaties were signed with US after years of fighting after encroachment on their land
- Two of the treaties were broken (by the US gov of course because you can't trust yt devils) and the third one sent them to the desolate reservation they're on when the game starts
- Leviticus Cornwall (greedy old white capitalist robber baron) wants them off their land for oil (for a trifecta of US bad/fossil fuels bad/capitalism bad), so he collaborates with US army Colonel Favours (old white man; Obviously racist, greedy, prideful yet cowardly) to push them out
- Arthur first encounters the tribe during the Saint Denis chapter, helping recover incriminating documents on Cornwall for Eagle Flies, son of the Wapiti chief
- During the Beaver Hollow chapter, Dutch wants to use the Indians as a distraction to help the gang's escape
- Arthur befriends noble chief Rains Fall as well as fellow white
savior ally Captain Monroe of the US army, who's also wholesome and not racist
- US army soldiers desecrate the sacred sites of the Wapiti people, cue:

- Arthur discovers the army is preventing the Wapiti from getting the smallpox vaccines (evil whitoid disease) they were promised which is bad news because the tribe is experiencing an outbreak (likely caused by infected blankets). Arthur, recovers the vaccines for the tribe with the help of Fauci's blessing
- Colonel Favours sets up a meeting to broker a deal with the tribe and through contrived bullshit Arthur finds out that actually there will be no concessions. Further, Monroe is going to be hanged for not being an evil white man! Arthur saves him and they flee. They then wipe out an entire army fort to save a captured Eagle Flies.
- The plotline concludes with the epic battle of the noble natives, fighting futilely on behalf of Mother Gaia, against the evil racist USA and the capitalist oil baron's goons. They assault and destroy Cornwall oilfields, valiantly slaughtering dozens of farmers' sons who were just serving their country
- In the end, the tragedy is not in the needless loss of life on both sides, but rather that Eagle Flies and his warriors were once again manipulated by the white man in Dutch
- The Wapiti flee to Canada, losing many of their own along the way (just like the Trail of Tears minus all of the Cherokees' black slaves) where nuns will presumably kill their daughters in boarding schools and bury the bodies in mass graves. Cornwall dies and tragically, there turns out there's no oil on the reservation. If only they had just gone green...