When Lucasfilm Games, later to be LucasArts, initially started making games, they were forbidden from making Star Wars titles for several years since Atari held the rights to the license to make Star Wars games. Ron Gilbert has said that if they had been allowed, they may have never taken a chance on adventure games.
Bill Farmer, who voices Sam in Sam & Max hit the road, is most famous for voicing Disney's Goofy. He can also be heard as the asshole that shouts "Enter your name, pilot!" on the first screen in TIE Fighter.
Wing Commander III and IV's casts included representatives from a number of popular Science Fiction and Fantasy film series- Mark Hammill from Star Wars and Corvette Summer, Malcolm McDonald from Star Trek, John Rhys Davies from Indiana Jones, and Thomas Wilson from Back to the Future. It also starred 80's porn star Ginger Lynn Allen.
John Romero's girlfriend during the development of Daikatana (Stevie "Killcreek" Case) was photographed for an online Playboy spread. Romero's current wife Brenda Romero designed a sim game based on the Playboy mansion.
Randy Pitchford is a stupid moron and Borderlands is totally gayass.
During development of the very first Command and Conquer Joseph D. Kucan, a.k.a. the guy that played Kane was literally just some guy helping setup the green screens. They need to do some test photoage and he was chosen to just make up random dialogue and shit for testing. But they liked his persona and acting so much they made him into Kane.
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Here is a random picture of Tim Cain the man that pretty much conceived of fallout as a universe at his desk.
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During development of Company of Heroes the game was prototype in the Impossible Creatures engine, and was supposed to be called Brothers in Arms (till gearbox named their own series it).
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Joe was a little bit more than just some Rando. He worked in various capacities at Westwood (he voices Brandon in the talkie version of Legend of Kyrandia, for example).