I think the fundamental fuck up of the setting/theme is that it's not one place. A good M:tG setting puts you in a place and tells you the bones of the setting's history through lore blurbs on commons and has just enough story told through the cards to give you the illusion that it was well thought out. Instead EoE has random scifi tropes slung together where Flash Gordon rejects and Fischer Price Mass Effect soldiers duke it out with H. R. Geiger space monsters and Illithids in a wide variety of places that are unrelated to each other.
I think you could make a cool Sci Fi setting in MtG but it has to be in one place. Like left behind tribes of technomancers and escaped experiments on a slowly failing ring world, or a star system in not-Warhammer that has been cut off from the rest of the galaxy by a not-warp storm for 500 years. I think the cards are a lot better in EoE but in a lot of ways it left me even more underwhelmed than Thunder Junction or Aetherdrift because while they were also kitchen sink settings at least they had member-berries from other MtG sets and not completely unrelated properties.