I listened to some of the isometric podcast. It's mostly a bunch of speds who can't make anything entertaining complaining about why it's wrong to find certain things entertaining. Add in some "oh so quirky" shenanigans, and a helping of pretend importance and that's about it.
The production values are fair, but the content is mind numbing.
It is interesting to listen to Wu interact, and to realize that people actually willingly hang out with her. Her personality isn't too much different from her tweets though, as in you can really tell how certain she is of being right.
I don't think there is really anything worth digging for, but I might listen to more and try to find a few choice quotes.