No ovaries required: viable eggs grown in a dish

No ovaries needed: viable eggs grown from mouse stem cells

Growing eggs from basically nothing!!!

cosmosmagazine.com

Scientists have successfully coaxed mouse stem cells to develop into functional eggs in a dish – that then grew into baby mice, according to a study published in Developmental Biology.

This has wide implications for assisted reproductive technologies in the future, because it may provide an alternative to egg donors.

A team of researchers, led by Takashi Yoshino of Kyushu University, Japan, developed culture conditions in a petri dish that imitated ovarian follicles to recreate the process that stem cells normally take to turn into eggs, which resulted in viable eggs. They called the lab-grown cells ‘reconstituted Ovarioids’ (rOvarioids).

Pluripotent stem cells are immature but have the potential to become almost any type of cell under the right conditions. In the ovary, these cells can become oocytes, which eventually turn in to eggs.

Normally, oocytes are encapsulated by ovarian cells in a fluid-filled follicle structure that help the oocyte undergo a round of meiosis (a type of cell division) and become an ovum (an egg that can be fertilised).

Previously, it was hard to grow the oocytes and ova in a petri dish because the ovarian follicles are essential in the process, so the team developed a culture as an “incubator” for the eggs to grow in, outside of the ovary.

The team took stem cells from mature female mice and placed them in the culture. This simulated the normal ovary environment so effectively that the stem cells developed into functional oocytes –rOvarioids – that could later be fertilised via in vitro fertilisation (IVF) and implanted into mice wombs.

Incredibly, 5.2% of the embryos derived from rOvarioids grew into babies after implantation, and all of the babies born via the method grew to adulthood.

This is comparable to the effectiveness of IVF-derived embryo transfer success in people over 43 years of age, but there is no restriction on the amount of eggs available, because lots of rOvarioids can be made.

“This technical breakthrough holds enormous potential for (reproductive) cell research,” says Lin Yang of the Genome Institute of Singapore.

Ying explains that this allows for high-yield IVF entirely without eggs or genetic manipulation.

Reconstitution of follicle structures, including oocytes, entirely from mouse pluripotent stem cells. Illustrations on the left show a schematic overview of reconstitution of both the ovarian filament cells (FOSLCs) and stem cell-derived eggs (PGCLCs) from mouse stem cells. Oocytes in the reconstituted environment gave rise to offspring after fertilization. The right image represents fully grown cumulus-oocyte complexes derived from FOSLCs (red) and PGCLCs (blue). Credit: Yoshino et al.

 

[Der weiße Teufel]

Cool story, but they still need a womb, so this won't replace women or help troons.

Though speaking of, this experiment is only slightly less horrifying than the one where they stitched male and female mice together and tried to get the male through pregnancy this way.

 

[Celebrate Nite]

Cool story, but they still need a womb,

yea, about that...

An artificial womb successfully grew baby sheep — and humans could be next

The lambs spent four weeks in the external wombs and seemed to develop normally

www.theverge.com

https://archive.is/sLHI7

Granted this was in 2017, but it's been in the works for some time.

 

[Exigent Circumcisions]

If experiments into using fetal stem cells to treat disease are anything to go by, these eggs will develop into Godless tumor monsters that beg for the sweet release of death.

 

[Atatata]

This will most likely just be used to keep certain animal species from going extinct, tbh.
Though, something like this might be a good back up just in case

 

[Garm]

Imagine using aborted babies to make these eggs. That would be some evil villain movie shit right there, effectively shortening the period between generations from two decades to less than a year. Do this for a few years and you'll be generations ahead of the human race.

Eventually you let these develop and it turns out they have 2 foreheads and 7 chins and faces only a mother could love. But they have no mothers because you aborted them to turn them into eggs. Loveless abominations.

And that's how you get the super soldier army that will destroy us all.

You can supposedly get stem cells out of people's noses which sides steps that whole issue.

yea, about that...

An artificial womb successfully grew baby sheep — and humans could be next

The lambs spent four weeks in the external wombs and seemed to develop normally

www.theverge.com

https://archive.md/sLHI7

Granted this was in 2017, but it's been in the works for some time.

Ah the Biobag. I had a feeling that feminism would lead to a Brave New World style nightmare. And we are at the cusp of it. I fully embrace it now because every step of the way these people could have stopped and considered what was happening. Instead they ran full speed into it.

"My body can create life."
"We made a machine that can do that."

 

[Ughubughughughughughghlug]

We should have legal abortion specifically for Luddites.

 

[Yamma Damma]

Hm. Interesting. Yesterday I got recommended a video about chicken eggs being incubated in glasses and watched it. Out of the dozen, only one was able to survive full term. Obviously growing in eggs is vastly different from growing in wombs but it was interesting though (the narrator's cheesy tone helped).

Goes without saying but doesn't matter what creature the zygotes come from, this is incredibly creepy. Pray that God doesn't blink from all this pissing in His eye lately.

 

[TowinKarz]

This will most likely just be used to keep certain animal species from going extinct, tbh.
Though, something like this might be a good back up just in case

It's what it should be used for, but it will be mandated to use it so trans loons can finally be "Real" women at last....

Thus are the wages owed to Clown World.

How many years have we been calling China a bubble now?

As many as the "experts" have been calling it the emerging new superpower of the globe.... neither outcome is true. It's not the new master of the planet, it's not a failed state, it's just continuing to be the shitty oligarchical dictatorship it's always been.

They're setting up ports and roadways that will ensure their dominance for centuries to come; do they have to see the rise of their God Emperor and declare the eternal mandate of heaven or something before we might consider them an economic threat?

Those roads and belts are not to spread their influence but to just put other nations in their debt slavery.... which will only work for as long as those other nations agree to keep paying the interest on the loans. Ultimately, they don't' have the power to project their army into Albania if they default on the loan the used to build the billion dollar bridge-to-nowhere . Yes, it's them consolidating their power, but in a way that only works if everyone else plays along, since they STILL don't have the force-projection they said they would have any-moment-now 1t years ago... as opposed to the US consolidation of power which is "Fuck around and find out" and we can back that up with a carrier task force in a week.

 

[Duke Nukem]

This and artificial wombs will be the beginnings of an incel clone army, no doubt.

 

[Billy Beer]

Abortions will be as easy as wiping clean a petri dish.

 

[Hecate]

aborting children to create children. what a world.

it says the stem cells were obtained from the adult female mice. now how technical they are being when saying "obtained from" is remain to be seen

edit: I read the actual study, the stem cells were mESC's (mouse embryonic stem cells). so they were in fact from mouse babies.

 

[Zero Day Defense]

I will enjoy the tantrums of women who will not be able to find a man because guys who want a legacy will just do this.

The Eternal Simp will pacify them, as he always has.

 

[Scale Smerch]

Dystopian future remarks aside, this is a pretty damn impressive development. Stem cell research has been in a sort of purgatory for a while now given the difficulty in actually inducing desired differentiation, so something like this is a major leap. If we can actually create viable oocytes it's quite likely we'll see lab-grown organs in the near future.

 

[Hecate]

Dystopian future remarks aside, this is a pretty damn impressive development. Stem cell research has been in a sort of purgatory for a while now given the difficulty in actually inducing desired differentiation, so something like this is a major leap. If we can actually create viable oocytes it's quite likely we'll see lab-grown organs in the near future.

agreed. im hoping that adult stem cell research advances further considering they lack some of the downsides that embryonic stem cells have (cell rejection by host, being tumorigenic, obtained from the destruction of viable embryos). I'd be very interested to see bone marrow and umbilical/placental stem research advance, as very recent research shows they may have the ability to change specialization like embryonic stem cells can.

imagine, a mother has a child and has the placenta saved for the future. if those stem cells can indeed be specialized into other cells that would mean they could be used to create new organs for not only her, but also for her child. organs that will not be rejected by the immune system and ones that do not have a higher chance to grow tumors, unlike embryonic stem cells.

 

[murdered meat bag]

it says the stem cells were obtained from the adult female mice. now how technical they are being when saying "obtained from" is remain to be seen

edit: I read the actual study, the stem cells were mESC's (mouse embryonic stem cells). so they were in fact from mouse babies.

can stem cells come anywhere else? they dont exist in adults.

 

[Zero Day Defense]

can stem cells come anywhere else? they dont exist in adults.

Actually, they do, but in much more limited quantities and with a smaller range of differentiation potential.

 

[murdered meat bag]

Actually, they do, but in much more limited quantities and with a smaller range of differentiation potential.

one day science will harvest the comatose and lame

 

[Zero Day Defense]

one day science will harvest the comatose and lame

I learned from a bio student some time ago that they were actually on a good path to concretely devising a way to create adult stem cells without any such harvesting, so at least the silent monster that's the medical industry isn't set to harvest cells from the vulnerable.

 

[Hecate]

can stem cells come anywhere else? they dont exist in adults.

check the post I made right before you. all adults have stem cells that are specialized, basically they can turn into different adult cells, but only of a certain "class", ie. muscle specialized stem cells can turn into different types of muscle cells, but not into cells for the immune system. recent research has shown that bone marrow and placental stem cells may be able to change outside of these "classes" like embryonic stem cells can, but I am unsure if any headway has been made in that field.

 

[BlerdBjern]

Stop. Playing. God.

I'm fuckign serious. Roasties and career women will probably pay out the assload for their tard baby with this surgery, though I suspect trannies might be the intended use in the end, so we gotta cater to them.

If god exists he's a fuck wit and I'm pretty sure even we can do better...

So lets keep playing god and Spit in the eye of nature!