I think its been said in this thread before that without Bethesda's rape of the IP, we would have never gotten New Vegas. And FNV is preferable to Van Buren, and I don't care what 30+homosexuals says, that game was going to suck and would have been the last entry in a franchise that would have been quickly forgotten.
On another note, I was thinking this morning about if F4's story could have been marginally better if the main character finds Nate in Diamond City looking for his son. You then go on a quest to help him find his son, but maybe in this version he's some Institute experiment instead of the leader.
Not that this fixes much, but the main quest is so retarded and so railroaded that I'd be happy with a change like this