JAMA: Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months (L | A)
Findings In this cohort study of 229 pregnant women and their children, a 0.68 mg/L (ie, 1 IQR) increase in specific gravity–adjusted maternal urinary fluoride during pregnancy was associated with nearly double the odds of T scores for total child neurobehavioral problems being in the borderline clinical or clinical range.
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Associations of MUFSG with raw scores for CBCL syndrome scales and
DSM-5–oriented scales are presented in
Table 3. A 1-IQR increase in MUFSG was associated with a 13.54% increase in raw scores for the Emotionally Reactive CBCL syndrome scale (B = 0.13; 95% CI, 0.02-0.24;
P = .02), and a
19.60% increase in raw scores for the Somatic Complaints CBCL syndrome scale (B = 0.18; 95% CI, 0.07-0.28;
P = .001). Additionally, a 1-IQR increase in MUFSG was associated with an
11.29% increase in scores on the DSM-5–oriented Anxiety Problems scale of the CBCL (B = 0.11; 95% CI, 0.003-0.21;
P = .045) and an
18.53% increase in scores on the DSM-5–oriented Autism Spectrum Problems scale of the CBCL (B = 0.17; 95% CI, 0.04-0.30;
P = .009).